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双歧杆菌生态制品对海人酸模型抗癫痫作用的初步观察
EFFECT OF UNTIEPILEPTOGENESIS OF BIFIDOBACTERIUM ON KAINIC ACID MODEL
【摘要】 用海人峻(KainicAcid,KA)10mg/kg给SDk鼠皮下注射,注射后0-1/2h之内,动物出现凝视和湿狗样抖动;1/2-2h,动物出现癫痫发作(严重程度从1级发展至5级);2h后,动物反复自发出现严重的癫痫发作;4h减弱;8h停止。实验组动物分别于1或3周前开始并连续从饮水中定量投喂双歧杆菌活菌制剂(0.5g/天/只)。结果表明,预先投喂该生态制品持续达3周组大鼠其癫痫发作受到明显抑制与对照组比较P<0.01。
【Abstract】 Within O-1/2h after the subcutaneous injection of kainicacid(KA 10mg/kgs.c.),the rats occurred:taring and wet dog shakes,1/2-2h,seizure episodes(stage 1-5)were developed; 2h after,the spontaneusreurrent seizures with intense salivation were exhibited;prolongedseizure episodes were decreased at 4h and ended at 8h later.In theexperiment group,which received bifidobacterium from drinking waterfor 1 or 3 weeks before the systemic KA,resrectively. The seizureepisodes vere only stippressed in the rats which have recelved bifido-bacterium for three weeks.
- 【文献出处】 中国微生态学杂志 ,CHINESE JOURNAL OF MICROECOLOGY , 编辑部邮箱 ,1995年03期
- 【分类号】R742.1
- 【被引频次】9
- 【下载频次】35