【摘要】 采用玻璃微电极胞外记录和脊髓表面给药的方法观察了催产素（ＯＴ）、抗催产素血清（ＡＯＴＳ）以及电针穴位对背角神经元伤害性诱发放电的影响。结果表明：电针穴位或脊髓表面施加ＯＴ可部分抑制脊髓背角神经元的伤害性诱发放电；在电针的基础上施加ＯＴ则明显加强电针的抑制效应；相反，用ＡＯＴＳ预处理后，电针的抑制作用被取消。提示ＯＴ在脊髓水平参与了对痛觉信息的调制，并与一定频率的针刺镇痛有关。更多还原

【Abstract】 The effects of oxytocin(OT),anti─oxytocin serum(AOTS)and electroacupuncture(EA)onthe nociceptive discharges of dorsal horn neurons in spinal cord evoked by peripheral noxiousstimuli were observed in 53 male Wistar rats.The results were as follows:The mean evoked activi-ty of dorsal horn4 neurons induced by noxious stimuli was inhibited by EA( 10Hz) or OT(35ng/20μl);When OT was applied on the surface of spinal cord,the inhibitory effect of EA wasmarkedly increased; Pretreatlnent with AOTS blocked or even reversed the inhibitory effect ofEA. The results indicate that OT not only increases the inhibitory effect of EA,but also directlyplays a role in mediating electroacupuncture analgesia at spinal cord levels.更多还原