【摘要】 目的:比较自发性高血压大鼠（SHR）和WKR大鼠血浆和血小板中神经肽Y（NPY）的含量, 以及ADP、凝血酶和胶原引起血小板聚集和NPY释放的差别.方法:应用放射免疫分析法测定血小板及血浆中NPY的含量.结果:SHR和WKR大鼠血浆NPY含量无明显差别,分别为2.1±1.0和1.8±1.0μg·L^-1,而SHR血小板中NPY含量(32±6 μg·L^-1)显著高于WKY大鼠(22±9 μg·L^-1).凝血酶和胶原可引起血小板聚集和NPY释放,SHR显著高于WKR大鼠;而ADP虽可引起血小板聚集,却不引起NPY释放.结论:SHR血小板中NPY含量增高、释放增多.更多还原

【Abstract】 AIM: To investigate the pathophysiological role of platelet neuropeptide Y (NPY) in hypertension. METHODS: The content of NPY in plasma and platelets from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKR) were measured by ra-dioimmunoassay. RESULTS: There was no difference in NPY concentration between SHR plasma and WKR plasma (2.1±1.0vs 1.8 ± 1.0μg·L-1), but higher amounts of NPY in SHR platelets than in WKR platelets (32±6 vs 22±9μg·L-1, P < 0. 05). The platelet aggregation and the release of NPY from platelets induced by thrombin and collagen were increased in SHR; ADP did not cause NPY release from platelets, although it produced severe aggregation in both SHR and WKR. CONCLUSION: The content of NPY in platelets and thrombin- and collagen-induced NPY release from platelets are higher in SHR than in WKR.更多还原