【摘要】 测定Ⅰ、Ⅱ期高血压病患者给予氨氯地平治疗四周前后平均动脉压（MAP）、淋巴细胞胞浆游离钙[Ca2+]i、血管紧张素Ⅱ（AugⅡ）及左室舒张功能指标（E，A，E／A）。结果显示：（1）治疗后MAP、[Ca2+]i、AugⅡ显著下降（P＜0.05）；（2）在室舒张功能指标（E，A，E／A）显著改善（P＜0．05）；（3）治疗后，[Ca2+]i下降幅度与MAP下降幅度呈正相关（r=0．597，P＜0.05）；AugⅡ下降幅度与MAP下降幅度亦呈正相关（r=0．454，P＜0．05）；[Ca2+]i下降水平与E／A比值升高幅度呈负相关（r=-0．483，P＜0．05）；AngⅡ下降水平与E／A比值升高幅度亦呈负相关（r=－0．449．P＜0．05）。提示：氨氯地平的降压和对受损的左室舒张功能改善机理，除通过纠正细胞钙代谢异常外．还可能与其对AngⅡ活性的抑制有关。更多还原

【Abstract】 Mean BP, lymphocytic intracellular free Ca2+,plasma Angiotensin Ⅱ. and left ventricular diastolic functionwere determined in patients with essential hypertension(stages Ⅰ, Ⅱ) before and after 4 weeks amlodipine treatment.The results showed: (1)MAP, [Ca2+]i and Ang Ⅱ were significantly reduced after treatment (P<0. 05 ); (2)Ieft ventricular diastolic function (E, A,and E/A ratio) were obviously improved (P< 0. 05 ) ; (3)the decrease in [Ca2+]i was positivelycorrelated with the decrease in MAP (r= 0. 597, P< 0. 05);the decrease in Ang Ⅱ was also positively correlated with thedecrease in MAP (r= 0. 454, P<0. 05 ); the descrease in[Ca2+]i was negatively correlated with the increase in E/A ratio (r= - 0. 483,P<0. 05) ; the descrease level of Ang Ⅱ wasalso negatively correlated with the increase level of E/A ratio(r= - 0. 449, P<0. 05 ). It is suggested: the mechanisms ofantihypertensive effect and irnprovernent of left ventricular diastolic function by amlodipine,might be associated to inhibitionon Ang Ⅱ activity and normalization of intracellular calciummetabolism.更多还原