【摘要】 本文利用大白鼠４血管结扎法建立脑缺血再灌流模型，同时制备脑组织线粒体和微粒体组分，检测假手术组，缺血１５ｍｉｎ，再灌ｌｈ、ｌｄ和３ｄ各组生物膜主要磷脂的含量变化，发现再灌流时磷脂代谢变化比缺血期幅度大，并且线粒体主要组成磷脂和微粒体主要组成磷脂代谢变化规律并不一致，证明磷脂代谢异常导致了生物膜功能丧失，造成了神经元的损伤。更多还原

【Abstract】 The brain ischemic reperfusion model was set up by rat 4VO method.Then the mitochondria and microsome fractions were purified respectivly by the same procedure. Their main phospholipids in normal group,ischemia 15 min group,reperfusion 1hr, 1 day and 3 days groups were tested. It revealed that the phospholipid metatolism changed more during reperfusion than during ischemia,and the phospholipid metabolisms of mitochondria and microsome were different. It suggested that neuron damage might be due to biomembrane dysfunction that resulted from the abnormality of phospholipid metabolism.更多还原