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山莨菪碱对蛛网膜下腔出血后基底动脉产生EDRF的作用及抗痉挛机制研究

Effect of anisodamine on production of endothelium derived relaxing factor following subarachnoid hem orrhage in rabbit basilar artery and its anti-vasospasm mechanism

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【作者】 宋德坤杨琼英何洁

【Author】 Song De-Kun,Yang Qiong-Ying,He Jie Department of Pathophysiology,Kunming Medical Colleg,unming(650031)

【机构】 昆明医学院病理生理教研室

【摘要】 用山莨菪碱(654-2)防治蛛网膜下腔出血(SAH)后脑血管痉挛,观察654-2对基底动脉中EDRF,MDA,SOD,cGMP,Ca ̄(2+),Na ̄+的影响。结果表明,应用654-2后降低了基底动脉中MDA产生及Ca ̄(2+)Na ̄+的含量,与SAH组比,EDRF释放增加,SOD活性及cGMP水平提高,基底动脉内皮细胞受到保护,基底动脉收缩幅度减小。提示,654-2可通过保护内皮细胞,减轻氧自由基损伤,拮抗Ca ̄(2+)Na ̄+在细胞内的蓄积,从而促进内皮细胞EDRF释放,引起血管舒张,明显减轻SAH后的脑血管痉挛。

【Abstract】 Anisodamine(654-2)was used to prevent the cerebral vasospasm fol-lowing subarachnoid hemorrhage(SAH ), and the effect of 654-2 on endothelium deriv-ed relaxing factor(EDRP) , malondiadehyde(MDA),superoxide dismutase( SOcGMP,Ca ̄(2+) and Na ̄+ in the basilar arteries were observed. Results showed that compar-ed with SAH group, while the rabbits were treated with 654-2 before and after SAH,the contents of MDA, Ca ̄(2+) and Na ̄+ decreased and release of EDRF increased in the basilar arteries. 654-2 also enhanced SOD activity and cGMP level of the basilar arteries. In turn it attenuated the endothelial cells injury and vasospasm of the basilararteries respectively. These results suggested that 654-2 may promcte the releaseof EDRF from endothelial cells by attenuate the injury of basilar arteries which wasinduced by free radicals and reduced Ca ̄(2+) and Na ̄+ accumulation in cells and finallypreventedthe cerebral vascspasm following SAH.

【基金】 国家自然科学青年基金
  • 【文献出处】 中国病理生理杂志 ,CHINESE JOURNAL OF PATHOPHYSIOLOGY , 编辑部邮箱 ,1995年04期
  • 【分类号】R965.1
  • 【被引频次】1
  • 【下载频次】26
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