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双（2，6－哌嗪二酮）类抗肿瘤药物的研究：2，3－二乙酰氧基－1，4－二（3′，5′－二酮－N4′－取代哌嗪甲基）苯的合成

STUDIES ON THE ANTIMETASTATIC BIS(2,6-PIPRAZINEDIONES):SYNTHESIS OF 2,3-DIACETOXY-1,4-BIS(3′,5′-DIOXO- N4′-SUBSTITUITUTED PIPERAZINYL METHYL)BENZENE

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【Author】 Q Li,X Shen,HW Shao and YY Xie(Shanghai Institute of Medica,Chinese Academy of Sciences, Shanghai 200031)

【摘要】双（２，６－哌嗪二酮）类抗肿瘤药物的研究：２，３－二乙酰氧基－１，４－二（３′，５′－二酮－Ｎ４′－取代哌嗪甲基）苯的合成李全，沈旭，邵华武，谢毓元（中国科学院上海药物研究所２０００３１）１９６９年Ｃｒｅｉｇｈｔｏｎ等人试图用ＥＤＴＡ与甲酰胺反应合成...更多还原

【Abstract】 Seventeen compounds having the structure of 2,3-diacetoxy-1,4-bis(3′,5′- dioxo-N4′-substituted piperazinyl methyl)benzene were designed and synthesized based on chelation hypothesis. Their antitumor activities on P388 cells,Hep cells and SGC 7901 cells in vitro were tested. Preliminary results showed that compound 4e has potent antitumor effect against P388 cells and.Hep cells in vitro.更多还原

【关键词】 2，3－二乙酰氧基－1，4－二（3′，5′－二酮－N4′－取代哌嗪甲基）苯；体外抗肿瘤试验；
【Key words】 Diacetoxy-1,4-bis(3′,5′-Dioxo-N4′-substituted piperazinyl mcthyl)benzene； Antitumor tests in vitro；

【文献出处】药学学报 ,ACTA PHARMACEUTICA SINICA , 编辑部邮箱 ,1995年06期

【分类号】R965
【下载频次】135

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