【摘要】 结核病人458例,使用9种抗结核药治疗,出现不良反应(ADRs)者86例,发生率18.8%,女性发生率(20.8%)稍高于男性(17.1%).不良反应共10种,其频度依次为听力、胃肠、前庭、肝损及过敏反应等.胃肠及过敏反应女性多,男性多见前庭及听力反应,肝损男女相近.各年龄组ADRs发生率14岁以下组最低(14.3%).药物中ADRs频度高的前三位为链霉素、利福平及PAS.链霉素以听力及前庭反应多见,利福平多为肝损,PAS全都出现胃肠反应.ADRs出现时间多在2个月内.ADRs严重程度以轻、中度居多.更多还原

【Abstract】 458 tuberculosis patients were surveyed. Nine kinds of tuberculosis chemotherapy drugs have been used. Adverse drug reactions (ADRs) were discovered in 86 cases. The incidence rate of ADRs was 18.8%. The ADRs incidence rate for female (20.8%) was higher than male’s (17. 1%). l0 kinds of ADRs appeared in 86 cases. According to the ADRs frequency from high to low it was hearing, stomach-in-testin, vestibule, liver injury, and allergic reactions etc. Stomach-intestin and allergic reactions were more often appeared in female patients and hearing and vestibule reactions were more found in male patients. Liver injury was approximately equal appeared in both sex. In each age groups the ADRs incidence rate of < 14a group was the lowest (14. 3%). The highest ADRs frequency of nine drugs was streptomycin, the second one was rifampin, and the third one was PAS. those three drugs were also more often to produce two kinds of ADRs. The more common ADRs of streptomycin were heating and vestibule reactions. Rifampin often injuried liver, and PAS usually produced stomach-intestin reaction. The appear time of ADRs in most cases were included into two months. Most cases were light and middle ADRs grade.更多还原