【摘要】 本文研究了在手性的顺式-γ-氨基-α,β-不饱和醛(7)与有机锂化合物的亲核加成反应中的1,4-不对称诱导效应。结果表明:7与α-烷氧基乙烯醇锂类化合物的反应导致了优良的非对映立体选择性(d.e.:60～90％),而与烷基锂试剂的反应也给出了高度的立体选择性(d.e.:74～86％)。这说明在这些反应中,存在着一种1,4-不对称诱导效应。更多还原

【Abstract】 The possibility of 1,4-asymmetric induction in some nucleophilic addition reactions of chiral γ-amino Z-enals 7 with organolithium compounds was investigated. The reactions of lithium enolates with 7 led to good diastereoselectivities (d. e.: 60- 90%), and high level of diastereoselectivities (d. e: 74- 86%) was also observed in the corresponding reactions of alkyllithium. This means that a novel remote 1,4-asymmetric induction results in these reactions.更多还原