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人脑恶性胶质瘤生物治疗的临床研究

Clinical Study of Biotherapy in Patient with Malignant Glioma of the Brain

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【作者】 惠国桢潘蔚然潘玉君王之敏朱凤清周岱鲍耀东徐庚达马文雄奚为乎杜子威

【Author】 Huo Guozhen, et al(The First Affiliated Hoopital of Suthou Medical College )

【机构】 苏州医学院第一附属医院脑外科!215006苏?

【摘要】 报告27例人脑胶质瘤生物治疗的临床结果,LAK细胞/IL-2治疗组12例,其中复发性星形细胞瘤10例,丘脑胶质瘤2例,有效率为33%。TIL/IL-2治疗组15例,星形细胞瘤及少枝胶质瘤均为术后肿瘤残留着,分别为12例和3例,有效率为47%。二组总有效率为40%。临床研究结果表明LAK细胞及TIL/IL-2是治疗人脑胶质瘤安全、有一定疗效的新途径。

【Abstract】 This study involves clinical results of 27 cases of brain malignant glioma, which is divided into two groups.The first involves 12 cases of LAK/IL-2 treated group among which 10 are recurrent astrocytoma, 2 are thalamus glioma. Of them, 2 have CR (complete response), 2 have PR (partial response), 3 wjth MR (minor response) and 5 with NR (no response), the therapeutic effectiveness reaches 33%. Another group involves 15 cases with treatment of TIL/IL- 2. Among them 12 cases bear with post-operative remnants of atyocytoma and 3 with residual oligedendroglioma, and their results are 3 cases of CR, 4 of PR, 6 or MR and 2 of NR, the clinic effectiveness reaches 40%. These clinical research findings point out that LAK cell and TIL/IL-2 treatment are effective comprehensive medical treatment with biological implement.

【基金】 江苏省科委资助
  • 【文献出处】 江苏医药 ,Jiangsu Medical Journal , 编辑部邮箱 ,1995年02期
  • 【分类号】R739.4
  • 【被引频次】6
  • 【下载频次】40
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