【摘要】 本文研究金丝桃甙（Ｈｙｐｅｒｉｎ，Ｈｙｐ）对中枢神经系统的一般药理作用。实验发现：①ｉｐＨｙｐ１２．５～５０ｍｇ·ｋｇ^－１呈剂量依赖性减少小鼠活动；②ｉｐＨｙｐ１２．５～５０ｍｇ·ｋｇ^－１轻度减少家兔的肺通气量但无明显量一效关系，且呼吸频率不受影响，ｉｖＣａＣｌ＿２可拮抗Ｈｙｐ减少肺通气量的作用；③ｉｐＨｙｐ１００ｍｇ·ｋｇ^－１不能拮抗士的宁所致的小鼠惊厥发作和死亡。上述结果表明：Ｈｙｐ具有镇静作用，虽减少肺通气但不抑制呼吸中枢节律活动。更多还原

【Abstract】 The general effects of hyperin on central nervous system were studied. The resultsshowed that hyperin could produce the dose-dependent sedation （12. 5～50 mg·kg￣（-1）, ip）but neither the hyponosis （150 mg· kg￣（-1）, ip） nor the anticonvulsion tested on the strychinine-induced convulsion model （100mg. kg￣（-1）, ip） in mice. It was also found that hyperin at doses of 12. 5～50 mg. kg￣（-1） （ip） could slightly decrease the respiratory volumes in a nondose-dependent manner with a ceiling rate of inhibition of 37.9% but not influence the frequencies of respiration in rabbits, and iv CaCl₂, could antagonize the negative effect of hyperin on the respiratory volume. So it is concluded that hyperin might be a depressant of central nervous system which differs from barbiturates, benzodiazepines and opioids.更多还原