【摘要】 用离体大鼠皮肤为渗透屏障，研究了盐酸普萘洛尔在杜促灵、油酸、Ａｚｏｎｅ作用下的透皮效果．在盐酸普萘洛尔的饱和水溶液中促进效果大小依次为５０ｇ／ＬＡｚｏｎｅ，１００ｇ／Ｌ杜促灵、２００ｇ／Ｌ．杜促灵、５０ｇ／Ｌ杜促灵、５０ｇ／Ｌ油酸，并且杜促灵的滞后时间比Ａｚｏｎｅ短．在聚乙烯醇为成膜材料，１００ｇ／Ｌ杜促灵为促进剂制成的膜剂用于家兔皮肤进行药物动力学研究．结果表明，盐酸普萘洛尔膜剂透皮给药后以零级方式吸收进入血液循环．更多还原

【Abstract】 The enhancing effect of several enhancers for the permeation of propranolol through excised rat skin was studied. The result showed that the permeation rate of propranolol from suspension solution decreased in following orders : 50 g/L Azone>100 g/L Lepaloine>200 g/L Lepaloine>50 g/L Lepafoine > 50 g/L oleic acid and lag time of Lepaloine was short than that of Azone.A tranedermal therapeutic system of propranolol hydrochloride with polyvinyl alcohol containing 100 g/L Lepafoine as a enhancer was prepaired to determine the plasma concentration of propranolol in rabbits after percutaneous absorption by high performance liquid chromatography. The results indicate that the pharmacokinetic process of propranolol patch could be described by zero-order kinetic mechanism.更多还原