【摘要】 为探讨左旋四氢巴马汀（ｌ－ｔｅｔｒａｈｙｄｒｏｐａｌｍａｔｉｎｅ，ｌ－ＴＨＰ）对门静脉压的影响及可能机理，观察ｌ－ＴＨＰ对正常大鼠和利血平化大鼠门静脉压的作用，并与哌唑嗪比较。结明表明：ｌ－ＴＨＰ使正常大鼠门静脉压下降２９．７９±９．７８％（Ｐ＜０．０１），并拮抗苯肾上腺素升高门静脉压的作用。大鼠利血平化后，哌唑嗪不再降低门静脉压，而ｌ－ＴＨＰ仍使门静脉压下降１５．９８±５．１７％（Ｐ＜０．０５）。提示α１受体阻断作用是ｌ－ＴＨＰ降低门静脉压的主要机理之一，α１受体以外降门静脉压机理亦共同参与作用。更多还原

【Abstract】 In order to study the effect of l-tetrahydropalmatine(l-THP)on portal venous pressure(PVP)and its mechanisms the changes of PVP following the administration of l-THP were observed in normal rats and reserpinized rats,and the effect of l-THP on PVP was compared with that of Prazosin.It was found that in normal rats,l-THP caused a marked reduction of PVP by 29.79±9.78%(P<0.001)and antagonized the pressor effect of Phenylephrine on PVP.In reserpinized rats,Prazosin failed to lower PVP,but l-THP still reduced the PVP significantly by 15.98± 5. 17%(P< 0.05)These results suggest that α1-adrenoceptor blockade is the main,but not the only mechanism of l-THP’s depressor effect on PVP;there must be other mechanisms,to In l-THP’s action更多还原