【摘要】 本研究应用药物青蒿琥酯片(100mg/片),在血吸虫病流行区鄱阳湖畔的3个自然村669例易感人群中,用双盲法进行预防日本血吸虫病的现场试验.试验对象在接触疫水后第7d开始服药,每wk1次,连服8次.青蒿琥酯剂量为6mg/kg,对照组服等量的安慰剂片.结果,346例服青蒿琥酯片者无1倒粪检血吸虫阳性;而服安慰剂的323例中有15倒粪检阳性,感染率为4.64%,EPG算术均数为312.0±1009.0,几何均数为37.08±5.3.青嵩琥酯的预防保护率为100%.本次试验不良反应轻微,头痛和腹痛的出现率仅1%左右,而且服药组和对照组的副反应出现率相似,各项实验室检查,包括血尿常规、肝肾功能及心电图等服药前后无明显改变.更多还原

【Abstract】 A double-blind study was conducted to determine the prophylactic efficacy of artesunate against schistosomiasis. The study was carrired out in 3 villages around the Poyang Lake,an endemic area of schistosomiasis. 669 cases were divided into two groups. The subjects in experimental group received artesunate 6 mg/kg once a week for 8 consecutive weeks after contacting with infested water for 7 days while subjects in control group received the same dosage of placebo. Results showed that after treatment,no case was egg-or miracidum-positive by fecal examination in experimental group(0/346),while 15 cases were positive in the control group with an infection rate of 4.64%(15/346). The EPGs of feces by arithmatic and geometric mean were 312. 0±1009. 0 and 37. 08±5.3 respectively. Adverse reactions of the drug were mild headche and abdominal pain. The adverse reaction rate was about 1%, and there was no difference between the two groups. No significant changes were found in routine blood examination, urine examination and liver function tests before and after treatment.更多还原