【摘要】 本研究主要观察吡喹酮(PZQ)对血清游离羟脯氨酸(F-Hyp)水平和肝脏虫卵肉芽肿(HEG)的作用.结果显示PZQ在减轻HEG及纤维化反应的同时,还可降低F-Myp的水平,表明F-Hyp水平能够反映肝脏胶原代谢的情况,可作为血吸虫性肝纤维化(SHF)诊断和疗效判断的一个指标.更多还原

【Abstract】 This study aimed at the effect of praziquantel on the related change of serum free hy-droxyproline (F-Hyp) and hepatic egg granuloma. The results showed that praziquantel decreased the F-Hyp content as well as depressed the hepatic egg granulomatous reaction and hepatic fibrosis. It indicated that the level of F-Hyp can serve as an index of the collagen metabolism in the liver.更多还原