【摘要】 用五管微电极细胞外记录的方法，观察在损毁皮层体感运动Ⅰ区（SmI）的条件下，微电泳导入吗啡对丘脑束旁核（Pf）神经元电活动的影响。结果显示：微电泳吗啡后6’－8’Pf神经元的伤害性反应明显减弱，与盐水对照组相比，两组神经元伤害性反应的差别有显著意义。提示：阿片肽参与Smi对Pf神经元的下行性调节。更多还原

【Abstract】 Neuronal responses in thalamic nucleus parafasciculus (Pf) to microiontophoretic rnorphine wereexamined in 20 wistar rats after lesion of SmI. Extracellular recordings were rnade with five-barreledglass microelectrodes. The results showed that the spontaneous responses of Pf neurons were not statistically changed (n= 11, P>0.05), but their nociceptive responses were attenuated at 0- 8 min utes after iontophoretic morphine (n=11, P<0. 05 ). There were statistically significant differencesin nociceptive responses between morphine and saline groups at 0-8 minutes after iontophoresis. Theresults suggest that morphine may be involved in corticofugal modulation of nociceptive responses inthalamic Pf neurons.更多还原