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131I-MIBG标记条件研究
A STUDY ON THE CONDITIONS OF THE METAIODOBENZYLGUANIDINE LABELLED WITH  ̄(131)I
【摘要】 介绍一种快速、简便的碘( ̄(131)I)标记MIBG(间位碘代苄胍)的新体系,抗坏血酸为还原剂,Cu(I)作催化剂,以醋酸、乙醇作为交换的介质。在一定条件下标记,标记率大于97%。稳定性跟踪实验说明,在室温下,一周内产品仍可满足临床使用要求。
【Abstract】 A new rapid method of  ̄(131)I labelled MIBG(Metaiodobenzylguanidine)was described.The la belling efficiency is more than 97%using Cu(Ac)2 as a catalyst,acetic acid,alcohol system as a medium of exchange reaction under the certain labelling conditions.The stability of labelled  ̄(131)I-MIBG cansatify the requirement of clinical application under the room temperature in a week.
- 【文献出处】 同位素 ,Journal of Isotopes , 编辑部邮箱 ,1995年01期
- 【分类号】R817
- 【下载频次】46