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灵芝在大鼠离体工作心脏观察其再灌注心律失常的功效以及对心功能的影响

EFFECTS OF LINGZHKGANODERMA LUCIDUM)ON REPERFUSION ARRHYTHMIA AND HEART FUNCTION IN THE ISOLATED WORKING RAT HEART

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【作者】 顾文缪永生江明华森昌夫

【Author】 Gu Wen,Miao Yongsheng and jiang Minghua(Department of Pharmacology, School of Pharmacy, Shanghai Medical University,Shanghai 200032 China)Masao Mori (Wakan Shoyaku Botany Institute,Tokyo Japan)

【机构】 上海医科大学药学院药理教研室日本和汉生药研究所 上海 200032 中国上海 200032 中国东京

【摘要】 0.3mg/mL灵芝浸出液显著减少离体大鼠工作心脏全心停灌—再灌注产生的室性早搏(PVC),3mg/mL非常显著地推迟再灌性PVC发生的时间以及显著降低全心停灌前的心率(HR)。

【Abstract】 In this experiment,the effects of Lingzhi(Ganoderma Lucidum)on reperfusion arrhythmia and heart function of isolated working rat heart was studied.The result showed that Lingzhi significantly reduced the number of PVC (premature ventricular complexes),postponed the occurring time of the first PVC and decreased the heart rate on the pre-is-chmia duration. However,it did not influence left ventricular pressure, coronary flow,aortic flow, ±dp/dt,left ventricular end diastolic pressure as compared with control group.

【关键词】 大鼠工作心脏灵芝心律失常再灌注
【Key words】 ratworking heartLingzhi(Ganoerma Lucidum)arrhythmiareperfusion
  • 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,1995年03期
  • 【分类号】R285
  • 【下载频次】97
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