【摘要】 应用彩色多普勒血流显像技术监测了３１例妊娠高血压综合征（以下简称妊高征）及７４例正常孕妇子宫胎盘血液循环变化，同时测定了血中雌三醇（Ｅ_３）、胎盘生乳素（ＨＰＬ）、血栓素Ｂ_２（ＴＸＢ_２）、６－酮－前列环素(６－ｋｅｔｏ－ＰＧＦ_１α)及ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_１α比值．结果：妊高征孕妇子宫动脉及胎儿脐动脉的时间平均血流速度（ＴＡＶ）、血流量（Ｑ）明显低于正常孕妇（Ｐ＜０．０５），尤以重度妊高征明显．妊高征病例经用硫酸镁及青心酮治疗后，子宫胎盘血液循环明显改善，子宫动脉及脐动脉的ＴＡＶ、Ｑ均增加（Ｐ＜０．０５）；其血中Ｅ_３及ＨＰＬ浓度明显低于正常孕妇，ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_１α比值明显高于正常孕妇．结果显示，用彩色多普勒观察妊高征患者的子宫动脉及脐动脉ＴＡＶ、Ｑ，可以直接反映子宫胎盘血供情况，为了解胎盘功能及宫内胎儿安危状况提供了一条有价值的参数．更多还原

【Abstract】 pregnant women with EPH syndrome and 71 normal ones were examined by using CDFI.The blood E3,HPL,TXB2,6-keto-PGF1α and ratio of TXB2/6-keto-PGF1αwere measured at the same time.The result showed that TAV and Q of uterine and umbilical arteries of normal pregnant women and fetuses were much higher that those with EPH syndrome(P<0.01). The circulation of placental blood flow was obviously improved and TAV and Q of uterine and umbilical arteries also increased after treatment with magnesium sulfate and Qing Xin Tong(P<0.05). The concentrations of blood E3 and HPL in the normal pregnant woment were much higher than those with EPH syndrome, whose ratio of TXB2/6-keto-PGF1a was significantly higher than those of normal ones. Our findings proved that TAV and Q of uteroplacental arteries in the patients with EPH syndrome, especially in the severe ones, were markedly lower than those in normal ones. Using CDFI to observe the velocity and volume of uteroplacental blood flow can directly reflect the condition of blood supply of uterus and placenta, thereby providing a valuable parameter of fetal situation and placental function.更多还原