【摘要】 为了解高血压时神经肽Ｙ（ｎｅｕｒｏｐｅｐｔｉｄｅＹ，ＮＰＹ）在动脉系统各级分支中的分布特征，作者采用自发性高血压大鼠（ＳｐｏｎｔａｎｅｏｕｓｌｙＨｙｐｅｒｔｅｎｓｉｖｅＲａｔｓ，ＳＨＲ）肠系膜动脉辅片技术，对血管系统进行全面、立体的观察。并用免疫组织化学、图像分析仪对血管壁上ＮＰＹ分布进行定性定量分析。结果表明，ＳＨＲ空肠动脉所属分支远侧中间段、远侧段（即小动脉和细动脉）ＮＰＹ分布表面积密度（分别为２０．５４±２．８８μｍ￣２／μｍ￣３、１３．９６±２．８７μｍ￣２／μｍ￣３）及ＮＰＹ显色物积分光密度（分别为２９．５３±２．６０、１０．４２±１．９８）均明显高于正常血压组。更多还原

【Abstract】 To comprehend the distribution characteristics of neuropeptide Y(NPY)in the branches of vasculature at all level in hypertension,we used technique of sheeting from mesenteric arteries in spontaneously hypertensive rats(SHR)to make a overall and 3-D observation of the vasculature;In addition,immunohistochemical technique and image analyser were used to analyse qualitatively and quantitatively NPY-containing innervation in the vasculature.Our findings showed that surface density of NPY-containing innervation(20.54±2.88μm2/μm3,13.96±2.87μm2/μm3,respectively)and integral luminous density of immunoreactive positive material for anti-NPY(29.53±2.60,10.42±1.98 respectively)in distal middle and distal region of jejunal arteries in SHR were significantly increased as compared with the findings in Wistar Kyoto(WKY).更多还原