【摘要】 采用冠状动脉（简称冠脉）内膜微电流刺激法进行犬冠脉血栓形成（ＣＡＴ）致急性心肌梗塞（ＡＭＩ）模型的实验研究。以冠脉血流量、血栓湿重和形态证实了ＣＡＴ形成，病理切片显示血栓构成与人类动脉血栓相似。心外膜心电图、血清肌酸激酶（ＣＰＫ）及心肌病检结果表明有心肌缺血和梗塞病灶产生，ＴＸＢ_２和ＴＸＢ_２／６－酮－ＰＧＦ_１α比值增高可能促发ＣＡＴ，ｃＡＭＰ增高诱发心律失常。ＡＭＩ首先损害心脏舒张性能，继而损害收缩性能，导致心脏泵功能下降。更多还原

【Abstract】 An experimental animal model for coronary arterial thrombosis（CAT） inducing acute myocardial infarction（AMI） was established by delivery of low amperage electric current to the intimal. surface of artery in dogs. The results showed that the coronary blood flow（CBF）was decreased to zero, the plasma TXB₂ concentration and ratio of TXB₂ over 6keto-PGF_1αwere increased, the plasma cAMP and CPK level were increased. In epicardialECG, the ST segment was elevated in association with appearance of Q wave. The thrombus was rich in platelet, with wet weight being 31.4±9.5g. It occupied the lumina of left circumflex coronary artery（LCX） and resulted in the formation of ischemic and infarct focus of heart. The myocardial ischemic size and infarct size amounted to 35.0±8.1%and 20.0±7.4%of left ventricular（LV）mass respectively. AMI and the elevation of plasma cAMP level might provoke ventricular fibrillation. After AMI, the LV dastolie function decreased first, followed by deterioration of the LV systolic function leading to failure of ventricular pumping function.更多还原