【摘要】 用改良Ｓｐｅｒｒｙ自身底物法分别测定了３４例正常人及１５８例肾脏病患者的血清ＬＣＡＴ活性，此法简便、重复性好。联合ＨＤＬ－亚组份检测不失为一种观察各种疾病所致脂质代谢异常的敏感指标。本文测定结果表明，肾脏病患者的血清ＬＣＡＴ活性较正常组显著降低，差异非常显著，证实肾脏疾患时伴有脂酶活性障碍。而且还发现尿毒症、肾炎患者存在低ＨＤＬ血症，尤以ＨＤＬ３降低为明显，而肾病组ＨＤＬ升高，但无统计学意义。唯ＨＤＬ２升高，分别与正常组、尿毒症组及肾炎组比较均有显著意义。更多还原

【Abstract】 e developed a modified method formeasuring lecithin- cholesterol acyltransferase (LCAT) , which is simpler than suchexisting techniques as artificial substrateadding method, isotope methods, etc, andwhich may be suitable for the routine assayof LCAT in clinical laboratory. Using thismethod, we observed the LCAT activity in158 patiebnts with kidney diseases and 34normal subjects. One hundred and fiftyeight patients were divided into three subgroups: uremia group (n = 47) , nephritisgroup (n = 31 ) and nephropathy group (n =80). Results showed that LCAT activity de-creased significantly in patints with kidneydiseases compared with normal subjects.HDL -subgroup was also detected, and wefound that HDL,especially HDL, decreasedin patients with uremia and nephritis,whereas in nephropathy group, there was ainsignificant increase in HDL.更多还原