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人血树状突细胞对T细胞增殖活性的影响

The Effect of PBDC from Human on Promoting T Lymphocyte Proliferation Stimulated by PHA in vitro

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【作者】 刘铁夫陈海滨廖传红张锦堃

【Author】 Liu Teifu,Chen Haibin,Liao Chuanhong,Zhang Jinkun(Department of Microbiology, Histology and Embryology, Shantou University Medical College)

【机构】 汕头大学医学院微生物学教研室

【摘要】 本文采用MTT法探讨了人外周血树状突细胞对T细胞增殖活性的影响。在50μg/mlPHA刺激下,T细胞增殖活性随树状突细胞浓度的增高而增强,培养上清中IL-1的活性亦随树状突细胞浓度的增高而增强。IL-1参与树状突细胞促T细胞增殖的作用机制。

【Abstract】 The effect of PBDC on promoting T lymphocyte proliferation stimulated by PHA in vitro was investigated by MTT method in this report. With the stimulation of 50μg/ml PHA, T cell proliferative rate was evidently enhanced by an increase in PBDC concentration. Simultaneously IL-1 activity in supernatant was also elevated. This might be involved in the mechanisms of PBDC in promoting T lymphocyte proliferation.

【关键词】 树状突细胞T细胞增殖IL-1
【Key words】 PBDCT Cell ProliferationIL-1
【基金】 国家自然科学基金
  • 【文献出处】 汕头大学医学院学报 ,JOURNAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE , 编辑部邮箱 ,1995年01期
  • 【分类号】R329.2
  • 【下载频次】32
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