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99mTc-IgG一步法药盒的研制及动物脓肿显象

ONE-STEP KIT OF  ̄(99m)Tc-IgG: ITS PREPARATION AND ABSCESS IMAGING IN ANIMALS

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【作者】 顾兆祥; 林祥通; 薛方平;

【Author】 Gu Zhaoxiang; Lin Xiangtong; Xue Fangping(Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical University, Shanghai)

【机构】 上海医科大学华山医院核医学科;

【摘要】 采用二硫苏糖醇还原IgG,研制成99mTc-IgG一步法药盒,并与配体交换二步法标记进行对比。该药盒稳定性好,标记率>95%,无菌、无热源。实验性金黄色葡萄球菌或松节油脓肿的家兔γ-显象表明99mTc-IgG在脓肿部位浓聚。

【Abstract】 The preparation of one-step kit for the 99mTc labeled human IgG with dithiothreitol reduction and a comparison of the one-step method with the ligand exchange method were reported,The stability was good,and labeling efficiency was over 95%. The sterility and free pyrogen in the kits were demonstrated. The scintigraphy imaging in the rabbits with staphylococcus aureus or turpentine-induced abscesses showed accumlation of 99mTc-IgG in the abscesses.

【关键词】 99mTc; 免疫球蛋白G; 核素显象;
【Key words】 ?99m)Tc; immunoglobulin; nuclide imaging;
【基金】 国家自然科学基金
  • 【文献出处】 上海医科大学学报 ,ACTA ATADEMIAE MEDICINAE SHANGHAI , 编辑部邮箱 ,1995年05期
  • 【分类号】R817.4
  • 【下载频次】13
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