【摘要】 利用⁸H-Prazosin结合试验和不可逆阻断剂N-ethoxycarboxyl-2-ethoxy-1,2-dihydroquinoline（EEDQ）测定了老年大鼠大脑皮质α₁-肾上腺素受体（α₁-AR）含量及α₁-AdR的受体动力学变化。老年大鼠大脑皮质α₁-AdR含量明显低于青年;老年与青年大鼠大脑皮质α₁-AdR的半恢复时间(T_1/2)分别为107.8h和64.1h,老年大鼠大脑皮质α₁-AdR的生成速率和降解速率常数分别为0.790pmol/（h·g蛋白）和6.43×10^-3/h,青年大鼠则分别为1.928pmol/（h·g蛋白）和0.0108/h。结果表明老年大鼠大脑皮质α₁-AdR更新缓慢。更多还原

【Abstract】 By using 3H-pra/osin binding assay and N-ethoxycarboxyl-2-ethoxy-l,2-dihydroquinoline (EEDQ), the densities of alpha-1-adrenoceptor and the receptor kinetics constansts of aged rats were measured. The alpha-1-adrenoceptor density of aged rats was lower than that of young rats (P<0.05). The 50% recovery times-of aged and young rats were 107.8h and 64.Ih; the reappearance rates of both rats were 0.790 pmol(h-g protein) and 1.928pmol (h-g protein); The constants of degradation of aged and yeung rats were 6.48×10-3/h and 0.0108/h respectively Our results showed that the recovery of alpha-1-adrenoceptor was slowed during aging.更多还原