【摘要】 用仙台病毒通过滴口鼻和腹腔注射感染８～１０周龄的清洁级ＢＡＬＢ／ｃ小鼠，１周后腹腔注射戊巴比妥钠６０ｍｇ／ｋｇ，测得仙台病毒感染组的睡眠时间为２８．２±１１．５ｍｉｎ，对照组为４１．６±９．３ｍｉｎ，２组的睡眠时间有显著差异（Ｐ＜０．０１）；另取４～７日龄清洁级ＢＡＬＢ／ｃ小鼠的肝脏进行肝细胞培养，设仙台病毒感染肝细胞组和正常肝细胞组，分别加入等浓度的心得安（３００μｇ／Ｌ），经高压液相色谱技术检测，仙台病毒感染肝细胞对心得安的代谢比正常肝细胞慢，２组间差异非常显著（Ｐ＜０．００１）。更多还原

【Abstract】 week-old BALB/c mice of clean category were inoculated with Sendai virus in both IP and O. N. routes, and injected with pentobarbital (60mg/kg) 1 week after the inoculation. Sleeping durations induced by pentobarbital of the test and control groups were 28. 2± 11. 5, 41. 6± 9. 3 minutes respectively (P<0. 01.test group versus control). Hepatic cells of 4-7-day-old mice were cultured, and infected with Sendal virus, then propranolol was added, very significant difference in the propranolol concentration was observed through HPLC between the test and control groups 20 minutes after propranolol being added (P<0.01). This suggested that Sendal virus infection maked the propranolol metabolism suppressed in the hepatic cells.更多还原