【摘要】 应用基因工程技术已研制出多种免疫毒素，ＩＬ－２免疫毒素是研究最为成功的例子之一，包括ＩＬ－２与绿脓杆菌外毒素的融合蛋白，ＩＬ－２与白喉毒素的融合蛋白等．这类毒素以ＩＬ－２为导向分子，ＩＬ－２受体阳性细胞为靶细胞，治疗移植排斥反应、自身免疫性疾病、Ｔ细胞淋巴瘤等疾病，在Ⅰ／Ⅱ期临床试验中已取得了较好的疗效．但是这类免疫毒素对人体均有较强的抗原性，使治疗时间和效果均受限制，为此研制了人源化的ＩＬ－２免疫毒素，能在体内外杀伤ＩＬ－２受体阳性细胞．更多还原

【Abstract】 Various kinds of immunotoxin have been prepared with genetic engineering method.The most succcessful one among them is interleukin-2(IL-2) immunotoxin,which consists of IL-2 protein fused with pseudomonas exotoxin or diphtheria exotoxin. The IL-2 moiety in this type of immunotoxin acts as a targeting ingredient,so that to kill the target cells positive for IL-2 receptors. The IL-2 immunotoxin is being applied to treat transplantation rejections,autoimmune diseases and T cell lymphomas , etc. So far,a promising therapeutic efficiency has been achieved during the Ⅰ/Ⅱ phase clinical trials.更多还原