【摘要】 为研究脂蛋白原接种阻断Ａｓ的免疫病理机理，将４２只新生乳兔随机分为对照组（Ⅰ）和２个实验组（Ⅱ、Ⅲ）。Ⅱ、Ⅲ组于生后１２ｈ内及第７、１５天分别向腹腔注射分离纯化的ＶＬＤＬ０．５ｍｇ／只、１．０ｍｇ／只。１８周开始喂高胆固醇饲科。第１７、３０、４０周检测总补体（ＴＣ），血清免疫复合物（ＣＩＣ），体外吞菌百分数（ＳＰ）和杀菌率（ＫＢＲ）。结果表明，１７周时Ⅱ、Ⅲ组ＴＣ明显高于Ⅰ组，３０周时ＴＣ仍明显高于Ⅰ组；ＣＩＣ显著低于Ⅰ组。４０周时Ⅱ、Ⅲ组ＳＰ，ＫＢＲ显著低于Ⅰ组。提示生命早期接种脂蛋白原能够阻断Ａｓ的免疫病理过程。更多还原

【Abstract】 Forty-two neonate NZW rabbits were randomly allocated into three groups i.e. control group Ⅰ and two experimental groups Ⅱ,Ⅲ .Groups Ⅱ, Ⅲ were injected with isolated and purified VLDL 0.5mg/individual 1.0mg/individual respectively in their abdomens within 12 hours after they were born, strengthened with the same dose at 7th ac well as 15th day. Since 18th week from bearing all of the rabbits were given high cholesterol diet.TC, CIC, SP, KBR were detected at 17, 30 and 40 weeks respectively. The result indicated that TC in groups Ⅱ, Ⅲ were much higher than that in group Ⅰ at 17 weeks. At 30 weeks, TC in groupz Ⅱ, Ⅲ were progressively higher than that in group Ⅰ,but the level of CIC were lower than group Ⅰ. At 40 weeks, SP, KBR were significantly lower than that in group Ⅰ. This study discovered that the inoculation with prepared VLDL in the early life stage had remarkable influence on the immune system. It has the inhibitory effect. on the atherosclerosis of aorta, however its mechanism needs to be studied deeply in further.更多还原