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岩黄连总生物碱对小鼠免疫功能的影响

Immunologic Effect of Corydalis Saxicola Bunting Total alkolids in Mice

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【作者】 童鲲; 吴练中; 梁益永;

【Author】 Tong Kun,Wu Lianzhing, Liang yiying(Department of Immunology and Microbiology,Medical Collegeof Yangzhou University,Yangzhou 225001)

【机构】 扬州大学医学院免疫学和微生物学教研室;

【摘要】 本文研究了岩黄连总生物碱(CSBTA)对小鼠免疫功能的调节作用,发现CSBTA在体内增强溶血空斑值和增强小鼠的迟发型超敏反应。在体外增强同种异型小鼠脾细胞的混合培养反应和增强有丝分裂原刺激脾细胞的增殖反应,另外CSBTA增强T细胞产生IL-2和IFN-γ的水平,提示CSBTA在免疫调节中是一种增强剂。

【Abstract】 The immunologic effects of Corydalis Saxicola Bu nt ing Total Alkolids(CSBTA in mice was observed in this study. It has been found that CSBTA was significantly increased the production of hemolysin plaque forming cell(PFC),delayed-type hypersensltivity(DTH)to allotypic spleen cell(ASC)in mormal mice. CSBTA could also enhance mitogen(ConA, PHA, LPS)induced murine splenocytes proligeration,the mixed lymphocyte reaction(MLR)of allogenic spleen cell and IFN-γproduction in normal mice and Con A-in- duced IL-2 production of murine splenocytes,The results suggest that CSBTA could be an enhancer in im-mune regulation.

  • 【文献出处】 免疫学杂志 ,IMMUNOLOGICAL JOURNAL , 编辑部邮箱 ,1995年04期
  • 【分类号】R392.5
  • 【被引频次】37
  • 【下载频次】250
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