【摘要】 为探索胃康在防治慢性胃炎过程中的作用机制,实验用160只Wistar大鼠自由饮用0.1％氨水8周造成实验性慢性胃炎,分防治和治疗两批进行观察。防治组在饮用氨水的同时每鼠分别用20％胃康,维霉素水溶液2ml隔日灌胃。治疗组于饮用氨水8周后,每鼠每日分别用30％胃康、维霉素水溶液灌胃治疗4周。两批动物均以尾部,眼球后取血测定GSH—Px活力和MDA含量。结果显示:无论防治组或治疗组,胃康都能显著提高全血GSH—Px活力(P<0.01),降低血清MDA含量(P<0.05),说明胃康具有一定的抗氧化作用。更多还原

【Abstract】 To investigate the mechanism of weikang on the prevention of expermental chronic gastritis, 160 wistar rats were given 0. 1 % ammonia solution as drinking at libitum for eight weeks to make the experimental model. The present work included two parts. The first one studied the preventive effects of weikang. among which the rats were infused simultaneously with 20% weikang and 20% weimeisu solution at 2ml every other day during the inducing period; The second part used as the therapeutic group, among which the rats were infused with 30% weikang and 30% weimeisu solution once every day for 4 weeks respectively after induced period. The blood samples were taken from tail and postocular veins for detection of Glufathione peroxidase (GSH-Px) activities and malodialahyde (MDA) levels for the two parts at the end of experiment. The results showed that weikang can inrease the GSH -Pχ activities markedly and decreased the MDA levels in both parts, which demonstrated that weikang had a definite anti-oxidative effects.更多还原