【摘要】 为深入探讨衰老、肿瘤演变以及癌基因活化之间的相关性,本文采用 Southern blot 技术检测196例不同年龄组别肿瘤组织中 C-erbB2癌基因的扩增频率。实验结果提示<35岁组中 C-erbB2癌基因的扩增率为26.92%,35岁～50岁组为36.89%,50岁～65岁为34.78%,而(?)65岁组可高达61.90%。经统计学处理提示:老年组与中年组相比有统计学意义(P<0.05).而老年组与青年组相比有显著性统计学意义(P<0.01)。由此可见,老年性组织癌变可能是由于某些原癌基因的活化所导致,进一步证实了衰老与癌变之间存在一定的相关性。更多还原

【Abstract】 Most cancer,especially of the solid tissue,increase markedly in incidence with age.This is consistant with the idea that cancer is due to the successive accumulation of a series of genetic changes.In order to study on the relationship between aging,oncogene activation and pathogenesis of human tumors,C-erbB2 gene amplification was detected in 196 tumor samples by use of Southern blot. 196 tumor samples were seperated into four groups due to their ages,including group I (<35 years old);group 2 (35～50 years old); group 3 (50～65 years old) and group 4 (≥65 years old).It was found that the positive rate of C-erbB2 gene amphfication was 26.92% in group 1;36.89% in group 2;34.78 % in group 3 and 61.90% in group 4 (P<0.01).These results suggested that aging human is involving in alteration of oncogenes and tumorogenesis.更多还原