【摘要】 本文通过小鼠在饮水中喂饲硫酸镍，观察到０．５５ｍｇ／ｋｇ染毒组体重下降。８０天后解剖，脏器系数与正常对照组相比，肝、脾均有非常显著的差别。光镜观察：局部心肌纤维、肾小管上皮细胞及肝细胞有轻度浊肿，脾脏明显萎缩。酶组织化学反应表明染毒组心肌ＡＴＰ酶活性略有下降而肾脏ＡＣＰ酶活性有所增高。电镜观察：染毒组见局部心肌细胞核溶解变性、肌丝模糊。肾小管上皮细胞线粒体肿胀，溶酶体增多。ｐ＜０．０１＊ｐ＜０．００２由表２可见高剂量组与正常对照组相比：肝脏的脏器系数有非常显著的差别（ｐ＜０．０１），脾脏的差别则更为显著（ｐ＜０．００２）。中剂量组大多数脏器系数与正常对照组差别不大，而脾脏也有显著差别…（ｐ＜０．０２）。２．３光镜观察２．３．１局部心肌纤维轻度浊肿，并偶见局灶性脂肪变。２．３．２部份肝细胞核轻度固缩或空泡变，胞浆浊肿（图２）。图２：高剂量组肝：肝细胞明显浊肿，部份核固缩或消失，Ｈ．Ｅ×３００２．３．３部份肾小管上皮细胞轻度水样变性，有的则肿胀变性、脱落（图３）。图３：高剂量组肾：部份肾小管上皮细胞水样变性，有的则明显肿胀。Ｈ．Ｅ×３００２．３．４脾脏明显萎缩。２．３．５少数动物胃粘膜上皮壁细胞增多；睾丸曲细精?更多还原

【Abstract】 In this study, the experimental mice were fed with nickel sulfate in drinking water.It was shown that the body weight of the group treated with 0.55/kg decreased. On day 80 the animals were sacrificed and their organ coefficients of liver andspleen compared to those of the normal control reduced obviously. Under the light microscopy there was local slight denaturationo of myocardium, renal tubule epithelium and hepatocytes, as well as evident spleen atrophy. Enzyme histochemical reaction indicated that activity of ATP enzyme in myocardium reduced while that of ACP in kidney was enhanced. In treated group moreover limited karyolysis and indistinct myofilament of myocardium and swelled mito chondria and increased lysosome in renal tubules there observed with electron microscope.更多还原