【摘要】 2名健康受试者一次po两种对乙酰氨基酚咀嚼片后,用高效液相法测定ab的血药浓度。其血药农度和过程符合一室模型。国产对乙酰氨基酚咀嚼片A（tempra A）的药代动力学为:T1/2Ka=0.3806±0.2816h,T_1/2K_e=1.761±0.8930h,T_max=0.9023±0.4179h,C_max=7.0728±1.2264mg/L AUC=26.8579±10.7680μg·ml^-1·h^-1。tempra B的药代动力学为:T_1╱2Ka=0.2993±0.2584h,T_1╱2Ke=1.9720±0.470h,T_max=0.8322±0.5263h,C_max=6.7487±2.1925mg/L,AUC=25.0871±5.7059μg·m1^-1·h^-1,国产对乙酰氨基酚痛咀嚼片与进口对乙酰氨基酚咀嚼片B（tempra B）的相对生物利用度为107.06％。提示两种对乙酰氨基酚咀嚼片的生物利用度相仿。更多还原

【Abstract】 After oral administration of two kinds of acetaminophen mastication tablets in 12 healthy volunteers, the plasma concentration of acetaminophen was determined by HPLC.The concentration-time profiles were fitted to one compartment model. The pharmacokinetic parameters for tampra A (Shanghai squibb phamarceuticals sass) were T1/2K. = 0.03806± 0.2816h, T1/2Kc = 1. 761 ± 0. 8930h, Tmax = 0. 9023 ± 0. 4179h, Cmax = 7.0728±1.2264mg/1 and AUC = 26. 8579 ± 10. 7680μg · ml-1 · h-1 for tempra B (Mead Johnson &. Company USA) were T1/2Ka = 0. 2993±0. 2584h, T1/2Kc = 1. 9720±0. 470h,Tmax = 0. 8322 ± 0. 5263h,Cmax=6. 7484±2. 1925mg/L and AUC = 25. 0871 ±5. 7059μg · ml-1 · h-1 Relative bioavailability of tempra A was 107. 06% compared with tempra B. It suggested that the tempra A be the same as tempra B in bioavailibity.更多还原