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新生儿同种免疫性血小板减少症

Neonatal Alloimmune Thrombocytopenia

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【作者】 金洁林修基

【Author】 Jin Jie;Lin Xiuji(The First Affiliated Hospital of Zhejiang Medical University,Hangzhou) Huhn A;Sachs V(Centre of Transfusion Medicine and Immunohematology,Kiel University,Germany)

【机构】 杭州浙江医科大学附属一院

【摘要】 应用固相血小板捕获试验对两例新生儿血小板减少症进行血小板特异性抗原(HPA)及血清中血小板特异性抗体的检测。结果发现,两位新生儿血小板特异性抗原为HPA-1,两位母亲为HPA-2,两位母亲及新生儿2血清中含有HPA-1抗体,证明为新生儿同种免疫性血小板减少症。讨论了本病的发病因素及治疗。

【Abstract】 Platelet specific antigens and platelet specific antibodies in two newborns with thromhocytopenia were detected with solid phase capture-P test.The result showed platelet specific antigens in two newborns were HPA-1 but those in two mothers were HPL-1.Two maternal and one neonatal sera were positive against HPA-1.The Study confired that two cases are of neonatal alloimmune thrombocytopenia.The pathogenesis and treatment of the disease were also discussed.

  • 【文献出处】 临床血液学杂志 ,JOURNAL OF CLINICAL HEMOTOLOGY , 编辑部邮箱 ,1995年03期
  • 【分类号】R593.1
  • 【下载频次】49
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