【摘要】 13例预激综合征(WPW)患者平均口服吗拉西嗪(Mor)588.5±41.6mg/d,至第7天时复查体表12导联心电图或(和)食管心房调搏(TEAP)或(和)三磷酸腺苷静注试验或(和)24h动态心电图,10/13例(76.9%)未显示出心室预激波,其中7例测定房室结前向有效不应期为268.6±90.8ms,Ⅱ°房室结文氏阻滞点为164.9±34.5bpm;1/13例(7.7%)心室预激波预缴成分减少;6/9例(66.7%)能有效地抑制房室折返性心动过速电诱发.提示,Mor对房室旁路前向传导具有强烈的选择性阻滞作用,若长期服用,大部分患者可望获得与旁路射频导管消融相似的疗效和预防高危WPW患者发生猝死.更多还原

【Abstract】 Electrophysliological test of moricizine (Mor) was performed in a total of 13 patients with Wolff-Parkinson-White syndrome (WPW) (manifest 11, latent 2). Routine 12 leads electrocardiogram or/and transesosphageal atrial pacing (TEAP) or/and intravenous adenosine tripho-sphate test were repeated at taking an average daily dose 588, 5±41.6mg of Mor for 7 days. The results showed an elimination of preexcited QRS complex (PEC) in 10 cases (76. 9%),of which 7 patients had a 268. 6±90. 8ms of anterograde effective refractory period and a 164. 9± 34. 5bpm of second-degree Wenckebach’s black point of atrioventricular node. A reduction of preex-ited component of the ventricular complex in 1 case (7. 7%). An effective suppression on induction of atrioventricular reentrant tachycardia (AVRT) in 6 of 9 cases (66. 7%) was observed. These results suggest that Mor has a potent selective block effect on anterograde conduction of accessory pathway and a suppressent efftct on induction of AVRT. If Mor is administered orally on a long-term basis ,it’s efficacy will be similar to that of radiofrequency catheter ablation of accessory pathway and sudden death can be prevented in high risk patients with WPW.更多还原