【摘要】 本实验在家兔胸主动脉内皮剥脱模型上，观察血管舒张反应的变化及其与血管平滑肌细胞增殖的关系。结果发现．内皮剥脱后血管对乙酰胆碱的内皮依赖性舒张反应明显降低。术后２周和４周时分别为对照组的２７．７±９．９％和５１．１±１１．４％；实验组和对照组血管对去甲肾上腺素的收缩反应和硝普钠的舒张反应均无显著性差异。内皮剥脱后血管平滑肌细胞显著增殖，内膜增厚。这些结果提示，内皮剥脱后血管的内皮依赖性舒张功能受损，内皮源性舒张因子产生可能减少；血管平滑肌细胞增殖可能与这些变化有关．更多还原

【Abstract】 Changes of vascular relaxation after balloon denudation of the rabbit aorta were investigated. Endothelium-dependent relaxation of ballooninjured vessels to acetylcholine was reduced significantly, 27. 7±9. 9% and 51. 1± 11. 4% of control at 2and 4 weeks after denudation, respectively. However,sodium nitroiprusside-induced relaxation and noradrenaline-induced contractile remained unchanged in the denuded vessel rings. After balloon denudation,vascular smooth muscle cell proliferation increased,and intima thickened. These findings indicated that function of vascular endothelinm-dependent relaxation was injured, and endothelum-derived relaxing factor production may diminished after balloon denudation.Vascular smooth muscle cell proliferation was related to these changes.更多还原