【摘要】 将马桑内酯作腹腔注射诱发大鼠慢性癫痫动物模型。然后，对模型动物和对照动物海马组织进行ＧＡＢＡ_Ａ受体γ_２亚单位的原位杂交组织化学研究。结果表明，慢性癫痫动物海马回和齿状回内的ＧＡＢＡＡ受体γ_２亚单位ｍＲＮＡ较对照组明显减少。提示ＧＡＢＡＡ受体γ_２亚单位可能在癫痫发病机理中起一定作用。更多还原

【Abstract】 The chronic epileptic mode was induced in rats by intraperitoneal injection of coriaria lactone.Then,the in situ hibridization histochemical study of GABAA receptor γ2 subunit was performed in hippocampal sections of model and control animal.The results showed that the GABAA receptor γ2 subunit mRNA in hippocampal and dentate gyrus were markedly decreased in sections of model animal than that in control,suggesting the GABAA receptor γ2 subunit might play some roles in epileptic pathogenesis.更多还原