【摘要】 应用放射姓免疫分析技术观察ｒｈＥＤＩＬ－８对大鼠晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_１α和ＴＸＢ_２含量的影响，并与ＭＡＢＰ的变化作相关性分析。结果发现晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_１α含量明显降低（Ｐ＜０．０１），ＴＸＢ_２含量明显升高（Ｐ＜０．０１）；给予ｒｈＥＤＩＬ－８（２５０μｇ／ｋｇ）静脉注射后血浆６～ｋｅｔｏ－ＰＧＦ_１α含量明显升高，其血浆水平与ＭＡＢＰ呈明显的正相关性（ｒ＝０．７４６）；ｒｈＥＤＩＬ－８对血浆ＴＸＢ_２含量却无明显影响。研究结果提示：ｒｈＥＤＩＬ－８抗晚期失血性休克作用与其促进血管内皮细胞产生和释放ＰＧＩ_２有关。更多还原

【Abstract】 The effect of recombinant human edothelial-dirived interleukin-8（rhEDIL-8）on 6-keto-PGF_1α and TXB₂ plasma contents in rats with hemorrhagic shock was studied by radioimmunoassay.The results showed that the plasma content of 6-keto-PGF_1α was significantly decreased（P<0.01） and the plasma content of TXB₂ was increased obviously（P<0.01） during profound hemorrhagic shock.After reperfusion and administration of rhEDIL-8（250μg/kg）,the plasma content of 6-keto-PGF_1α was remarkably increased and its levels significantly correlated with that of mean arterial blood pressure（r=0.746）.But rhEDIL-8 has not obvious effect on TXB₂ plasma content.The results suggest that rhEDIL-8 enhance vascular endothelium release PGI₂ may be the mechanisma of its antishock effects.更多还原