【摘要】 应用人精子与去透明带金黄地鼠卵受精技术制备人精子染色体标本,对正常男性240个精子核型进行了分析。结果显示,数目畸变精子率为3.34％,结构畸变精子率为6.67％。所观察到的结构畸变类型为无着丝粒断片、染色体断裂、双着丝粒体、易位、和染色单体断裂。在正常男性精子染色体组中,X-精子与Y-精子的比例为49.17％:50.83％;近端着丝粒染色体随体联合呈随机分布,随体联合频率为0.096。更多还原

【Abstract】 Using interspecific in vitro fertilization between zona-free hamster oocytes and human spermatozoa,240 human sperm chromosome complements were analyzed. The results showed that the rates of spermatozoa with numerical and structuralaberrations were 3.34%, 6. 67% respec- tively. The observed type of structural chromosome aberrations was fragment, break, dicentrics, translocations and chro-matid break. The ratio of X- to Y- sperm was 49. 17% to 50. 83%. The random distribution of satellite association (SA) of acrocentrics in human sperm chromosome complements was demonstrated, and the frequency fo SA was 0. 096. Some results were discussed.更多还原