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甘糖酯在小鼠体内的药代动力学研究

STUDIES ON THE IN VIVO PHARMACOKINETICS OF PROPYLENE GLYCOL MANNURATE SULFATE IN MICE

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【作者】 盛少虎李应全马剑峰袁玮

【Author】 Sheng Shaohu,et al.(Dept. of Pharmacology,Shandong Medical University, Jinan 250012)

【机构】 山东医科大学基础部药理教研室山东医科大学基础部药理教研室 济南 250012济南 250012济南 250012

【摘要】 用同位素标记法研究了[3H]甘糖酯1次灌胃后在小鼠体内的药代动力学,其血药浓度——时间曲线符合一室开放模型。小鼠灌服[3H]甘糖酯25mg/kg(4.48MBq/kg)后的药动学参数为:t1/2Ka 0.24h;t1/2β67h,Vd921mL,Cl9.58ml/h,AUC41.45mg/(mL·h),F79.3%,PPB54.9%。该药广泛分布于肝、肾、脾、胸腺、肾上腺、肺、心、肌肉和脑内。主要经尿道与粪便排泄。

【Abstract】 The in vivo pharmacokinetics of Propylene Glycol Mannuratae Sulfate (PGMS) after acute administration in mice was studied by the radio isotope assay. Its concentration -time curve fitted the one -compartment model. The pharmacokinetic indice of oral administration of PGMS 25 mg/kg are as follow;t1/2 Ka 0. 24 h,t1/2 B 67 h,Vd 927 mL,C1 9. 58 mL/h,AUC 41. 45 ng/(ml - h), F 79. 3%,PPB (plasma protein binding) 54. 9%. The drug was widely distributed in the liver,kidney,spleen,thymus,adrenal gland,lung,heart, muscles and brain,and excreted mainly through urine and feces.

  • 【文献出处】 中国海洋药物 ,Chinese Journal of Marine Drugs , 编辑部邮箱 ,1995年02期
  • 【分类号】R285.5
  • 【被引频次】8
  • 【下载频次】90
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