【摘要】 用同位素标记法研究了[³H]甘糖酯1次灌胃后在小鼠体内的药代动力学,其血药浓度——时间曲线符合一室开放模型。小鼠灌服[³H]甘糖酯25mg/kg（4.48MB_q/kg）后的药动学参数为:t_1/2Ka 0.24h;t_1/2β67h,V_d921mL,Cl9.58ml/h,AUC41.45mg/（mL·h）,F79.3％,PPB54.9％。该药广泛分布于肝、肾、脾、胸腺、肾上腺、肺、心、肌肉和脑内。主要经尿道与粪便排泄。更多还原

【Abstract】 The in vivo pharmacokinetics of Propylene Glycol Mannuratae Sulfate (PGMS) after acute administration in mice was studied by the radio isotope assay. Its concentration -time curve fitted the one -compartment model. The pharmacokinetic indice of oral administration of PGMS 25 mg/kg are as follow;t1/2 Ka 0. 24 h,t1/2 B 67 h,Vd 927 mL,C1 9. 58 mL/h,AUC 41. 45 ng/(ml - h), F 79. 3%,PPB (plasma protein binding) 54. 9%. The drug was widely distributed in the liver,kidney,spleen,thymus,adrenal gland,lung,heart, muscles and brain,and excreted mainly through urine and feces.更多还原