【摘要】 乙酰胆碱（Ａｃｈ）、去甲肾上腺素（ＮＥ）是脑内两种重要的神经介质。为探讨脑内Ａｃｈ、ＮＥ活动的脑波涨落图特征，给２０只家兔脑室分别注射浓度为５ｍｇ／ｍｌ的Ａｃｈ、ＮＥ各１０μｌ，记录左、右前脑，左、右后脑四个部位的皮层ＥＥＧ，用脑波涨落图技术（ＥＴ）的最优谱线、优势谱、谐振等指标进行分析。发现Ｓ５与脑内Ａｃｈ活动有关，在Ａｃｈ作用下，Ｓ５系增加，出现Ｓ５、Ｓ１０、Ｓ１５强谐振系列。同时Ｓ３系增强，且Ｓ３／Ｓ４显著高于对照组（Ｐ＜０．０１），说明Ａｃｈ对中枢有兴奋作用。Ｓ７脑内ＮＥ活动有关，但ＮＥ作用复杂，对中抠主要有抑制作用，也有弱兴奋效应。在ＮＥ作用下，主频段呈抑制趋势，优势谱中Ｓ３、Ｓ４、Ｓ５系明显减少，但Ｓ７系增加明显，其值最大。谐振分析发现Ｓ７系谐振增加，Ｓ３、Ｓ５系谐振减少，反映脑内ＮＥ的作用与５—ＨＴ和ＡＣｈ的作用相拮抗。同时（Ｓ２—Ｓ１）的值（Ｐ＜０．０１）、Ｓ３／Ｓ４（Ｐ＜０．０５）均显著增加，表明ＮＥ有一定的兴奋作用。更多还原

【Abstract】 ln order to clarify the actions of Ach and NE on encephalofluctuography,EEG was recorded in twenty rabbits after Ach or NE(10 ul,5 mg/ml) was slowly injected into the first ventricles of the brain and analysed with encephalofluctuography technology(ET) for predominant spectra,S spectra,and S harmonic oscillations。It was found that S5 series increased and harmonic oscillations of S5,S10,S15 appeared under the effect of Ach. It suggested that Ach has an exciting effect on the brain be-cause S3 series increased concomitantly and the value of S3/S4 was significantly higher than that in control rabbits。After injection of NE,S7 series and harmonic oscillations of S7 series increased distinct-ly while S3,S4 and S5 series and their harmonic oscillations decreased obviously. Additionally,the val-ue of S2-S1 and S3/S4 increased significantly。 These results suggested that S7 has relation with the action of NE in the brain and NE has not only inhibitory effect,but also certain exciting effect。更多还原