【摘要】 测定了示踪浓度下Ｇａ（Ⅲ）在ＨＣｌ－乙酸丁酯体系中的分配比Ｄ。实验表明，ＨＣｌ浓度为６ｍｏｌ／ｌ时，Ｄ值最高，达５×１０￣２。当相比为１，ＨＣｌ浓度为５．５－８．０ｍｏｌ／ｌ时，萃取率Ｅ≥９８％。在相同条件下，共存的ＺｎＣｌ＿２浓度＜２ｍｏｌ／ｌ时，Ｅ不低于９６％。采用乙酸丁酯萃取法从质子束照射后的Ｚｎ靶中制备枸橼酸镓［￣（６７）Ｇａ］注射液。萃取酸度为６ｍｏｌ／ｌＨＣｌ，Ｚｎ离子浓度≤２ｍｏｌ／ｌ，萃取前用ＴｉＣｌ＿３还原痕量Ｆｅ（Ⅲ）为Ｆｅ（Ⅱ），Ｇａ（Ⅲ）用水反萃。产品的核纯度～１００％，放化纯度＞９０％，Ｚｎ、Ｔｉ、Ｆｅ、Ｃｕ、Ｃｄ、Ｐｂ的浓度低于或接近１ｍｇ／ｌ，异常毒性检查合格，各项指标均符合中国药典和美国药典要求。化学产率为（９２±２）％，制备时间＜３ｈ。更多还原

【Abstract】 The distribution ratios D for Ga（Ⅲ）at trace concentration in the HCl-butylacetate extrac-tion svstem are measured.It is showed that tHe D in 6 mol/l HCl 5×10￣2 which is maximum in 3-8mol/l HCl.The extraction rates E in 5.5-8mol/l HCl at phase ratio of 1 are≥98%and≥96%respectively when the concentration of ZnCl₂ in the solution are 0 and≤2mol/l.A buty-lacetate extraction method for the production of ￣（67）7Ga citrate injection liquid from Zn target irradi-ated by proton beam is developed.The optimal acidity of extraction is 6 mol/l HCl.The concen-tration of ZnCl₂ is adjusted to≤2.0mol/l and the impurity of Fe（Ⅲ）in solution is reduced toFe（Ⅱ）with 10%TiCl₃ before extraction.The ￣（67）Ga in organic phase is then stripped with water.The radionuclidic purity of the product is 100%while the radiochemical purity > 90%.Theamounts of Zn,Ti,Fe,Cu,Cd and Pb in the injection are below or near 1mg/l.The test of abnor-mal toxicity is negative. The quality of the injection meets the requirements of both the ChinesePharmacopoeia and the United States Pharmacopoeia. The chemical yield is（92±2）%while thetime of operation is<3h.更多还原