【摘要】 用特异性放免法测定33例高血压患者血浆甘丙素(GAL)水平,结果显示高血压患者的血浆GAL水平(19.57±1.74Pg/ml)明显高于对照组(9.36±0.94Pg/ml,P<0.001)GAL与平均动脉压(MAP)呈正相关(P<O.05)GAL与内皮素(ET)呈正相关(P<O.001).自发性高血压大鼠(SHR)血浆GAL水平亦明显高于正常大鼠(P<0.001),GAL与MAP亦呈正相关(P<0.05),提示GAL是高血压的重要发病因素之一,体内多种多肽活性物质的增加,可能促进了高血压的发生与发展.更多还原

【Abstract】 The level of plasma galanin (GAL) was studied in 33 cases with hypertension andSHR (n=10)with radioimmunoassy. The results showed that plasma GAL level in patients withhypertension (19.57±1.74Pg/ml)was higher than that in normal subject (9.36±0. 94Pg/ml,P<0.001).A positive corrlation between plasma GAL and MAP (r=0.462,P<0.001). GAL andendothelin (ET) (r=0.790,P<0.01) was found. It was found that plasma GAL level elevatedsignificantly in SHR (P<0.01). A positive correlation between plasma GAL and MAP (r=0.543 ,P<0.05) was found. These data suggested that increase of plasma GAL may play an important role in the pathogenesis of hypertension.更多还原