【摘要】 卤代苯对酵母菌的毒性研究廖宜勇，刘征涛，王连生（南京大学环境科学与工程系南京２１００９３）关键词：卤代苯；酵母菌；毒性评价。酵母菌是一类真核微生物，它的细胞结构及功能与高等生物真核细胞相似，化合物对酵母菌的毒性与对真核细胞生物的毒性有良好的相关性￣［...更多还原

【Abstract】 The toxicity of halogneated-benzene to Saccharomyces cereviszae was measured by theminimum sample concentration which produced clear inhibition zone on pre-seeded agarplate. The samples were dissolved in DMSO-Glycol（80 : 20（W/W） ）carrier solvent.TheresuIts were correlated with n-octanol/water partition coefficient and molecular connectivityindices.log(1/C_min)=0.773 logK_ow-0.834,R=0.985,S=0.815,N=14log(1/C_min)=0.2950°X￣v+0.6721X￣v-2.57,R=0.989,S=0.0743,N=14The results were also compared to the toxicity of halogenated-benzene to photobacteriumphosphoreum,fathead minnow and rat,which were also correlated with each other. Theregression of the toxicity to Saccharomyces cerevislae on the toxicity to fathead minnow andthe regression of toxicity to Saccharomyces cerevisiae on the toxicity to rat had almost thesame slope（0.993 and 0.973 respectively）,while on the toxicity photobacterium phospho-reum 1.52,which means the toxic effect to eucaryotic Saccharomyces cerevisiae and to fat-head minnow and rat are at same level.更多还原