【摘要】 采用放射自显影技术观察自然衰老大鼠几个重要脑区Ｍ１受体密度的变化及知母或其甙元ＺＭＳ的调整作用．图像分析仪给出不同脑区的平均灰度（相对值），老年鼠皮层、海马、纹状体的灰度显著低于青年鼠，皮层和纹状体降低１５％左右，海马降低不到１０％．给开始进人老年期的大鼠长期口服知母或其甙元ＺＭＳ，三个脑区的Ｍ１受体密度均明显高于老年对照组．所以知母或其甙元ＺＭＳ能减轻衰老时上述三个脑区Ｍ１受体密度的降低，使之在较长时间内保持接近正常的水平．更多还原

【Abstract】 The cholinergic M1 muscarinic receptors in brains of aged rats and the regulation effects of ZM (Anemarrhena asphodeloicles Bunge) and its sapogenine ZMS were studied with autoradiography of 3H-pirenzepine. The mean grain densities in different brain areas were estimated by a computerized image-analysis system. The specific bindings of aged rats were decreased by 15% in cerebral cortex and striatum and by nearly 10% in hippocampus. Parallel experiments showed that chronic daily oral administration of ZM or its sapogenine ZMS to aged rats can attenuate the decrease of M1 receptor densities of the above three areas and keep them nearly normal for a long time.更多还原