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放射示踪术研究肾显像剂99mTc-PAHIDA的体内代谢特性

Study on the metabolic characteristics of renal imaging agent  ̄(99m)Tc- PAHIDA with tracer experiment

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【作者】 朱寿彭王六一伦明跃王国林赖冠华曹根发杨淑琴钟慎斌

【Author】 Zhu Shoupeng;Wang Liuyi;Lun mingyue;wang Guolin;Lai Guanhua;Cao Genfa;Yang Shuqin;Zhong Shenbin(Suzhou Medical College,Suzhou 215007)

【机构】 苏州医学院

【摘要】 观察表明,99mTc-PAHIDA在体内优势定位于肾脏,而后依次为心脏、胃肠道、肝、脾、股四头肌、脂肪、睾丸和脑组织。摄人99mTc-pAHIDA的量愈低,在肾脏的选择性浓集程度就愈高,与血浆蛋白的结合程度就愈低.99mTc-PAHIDA可迅速经肾脏排出体外,而且由尿色层分析放射自显影观察得到一个放射峰,从而证明它在体内是以原形经尿排除的。

【Abstract】 Tracer experiment showed that 99mTc-PAHIDA was distributed predominantly in kidney.The distribution in other tissue was in the following descending order: heart,gastrointestinal tract, liver, spleen, muscle, adipose tissue, testes, and brain. The smaller the intravenous dose, the lower the proportion of the drug was combined to plasma protein and the more the drug was distributed in kidney.Excretion of 99mTc-PAHIDA via urine was rapid and was in its original form as shown by radiochromatogrphy.

【关键词】 肾显像剂99mTc-PAHIDA代谢
【Key words】 enal agent99mTc-PAHIDAMetabolism
  • 【分类号】R817.1
  • 【下载频次】16
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