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肺癌患者血清视黄醇含量的临床研究
RESEARCH ON SERUM RETINOL LEVELS OF PATIENTS IN LUNG CANCER
【摘要】 本文利用高效液相色谱法测定了80例肺癌患者血清视黄醇含量,并以100名正常人作为正常对照组,50例糖尿病患者、40例肺结核患者分别作为病理对照组。结果表明,肺癌组视黄醇含量1.62±0.02umol/L,显著低于正常对照组(2.33±0.58umol/L)、糖尿病组(2.46±0.01umol/L)和肺结核组(2.06±0.12umol/L),P<0.01。有52.5%的肺癌患者处于视黄醇缺乏状态。血清视黄醇含量在鳞癌、腺癌和未分化癌三个病理类型间有逐渐下降的趋势。我们认为维生素A类可以控制上皮细胞的分化,缺乏时即可增加了机体对化学致癌物的敏感性,发生癌的机率增大。
【Abstract】 Serum retinol of patients in lung cancer was measured in this thesis with the method of high pressure liquid chromato-graphy(HLPC).The results showed that the level of retinol of patients in lung cancer was 1.62μmol/L and significantly higher than those of normal and abnormal control groups(p<0.01).52.5%(42/80)patients in lung cancer were in the state of deficient retinol.The levels of serum retinol among three pathological types(i.e.sqamous carcinoma,adenocarcinoma,anaplastic carcinoma)were different.It suggests that vitamin A control the epithelial cell differentiation.The deficiency of retinol may increase host’s susceptibility to chemical carcinogen.Therefore, the subsequent risk of development of lung cancer is high.
- 【文献出处】 河北医学 ,HEBEI MEDICINE , 编辑部邮箱 ,1995年03期
- 【分类号】R734.2
- 【被引频次】1
- 【下载频次】38