【摘要】 用图像分析仪观察麻醉状态下自发性高血压大鼠（SHR）及正常血压WKY对照大鼠提睾肌微循环变化．发现，SHR第一、二级微动脉管径分别显著小于WKY大鼠（－30％、－20％）．SHR各级微血管均变稀疏，在7／20只SHR及6／20只WKY大鼠中观察到血管运动．仅见于第三、四级微动脉．大鼠血管运动的振幅现象在第四级微动脉振幅SHR显著高于WKY大鼠．提示，在大鼠自发性高血压时．外周血管阻力增高除与较大的微动脉管径变小外．尚与微循环血管数的减少有关．更多还原

【Abstract】 Cremaster tnuscle preparations was used to study tLe microci rculation in8-week old spontaneously hypertensive rats (SHR ) and normotensive wistarkyoto control rats (WKY ) tinder the condition of anaesthesia. Morpho-metric study was made for analys is of consecutive segments of the vascular bed.Resting diameters of the first-order and second-order arterioles were sig nificantly smaller in SHR rats than in WKY rats (-30% and -20% respectively ). Rarefact ion of m icrovascular vessels was obse rved in all-order arterioles of SHR. In 7 of 20 SHR rats and 6 of 20 WKY rats. vasomotion was noticed in the 3rd- and 4th-order arterioles .Vasomotion amplitude of the 4th-order arterioles was significantlyLigher in SHR rats than in WKY rats. It is concluded that in spontaneous hypertension both decreased diameter of larger arterioles and rarefaction of microvascular vessels are involved in the major mechanism of the increased vascular resistance.更多还原