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黔园九号芦笋抗小鼠肿瘤作用及毒性研究
A Study on Toxicity of Asparagus-Qianyuan 9 and its Resistance Against Tumors in Mice
【摘要】 研究黔园九号芦笋原汁的毒性和抗癌作用。实验表明按每日723mg/kg体重灌胃,对小鼠可移植肿瘤、子宫颈癌U14、肝癌H22有抑制作用,平均抑癌率为32.4%。对实体型Ehrlich腹水癌(EAC)抑癌作用不明显,对肉瘤S180没有抑制作用。对T739小鼠的移植性肺癌LA795无抑制作用,也不影响癌的肺转移。小鼠口服LD50为6700±292mg/kg体重,按此剂量的1/9每日一次经口给药30天,对小鼠的生长发育有抑制作用。
【Abstract】 We studied the toxicity of extract of Asparagus-Qianyuan 9 and the role of the extract to resist tumors, Experimental animals were fed on Asparagus extract at the dose of 723 mg/kg Bw/d. We show that Aspargus-Qianytuan 9 had suppressive function in mouse-transplantable tumors, carcinoma of cervix uteri U14 and hepatocarcinoma H22. The everage inhibition rate was 32.4%. However, solid carcinoma EAC was not suppressed efficiently. Asparagus had effect on neither sarcoma S180 nor transplantation pulmonary carcinoma LA795 of T739 mice. Also, no effect on metastasising of carcinoma to lung by the extract was found. Toxicity study of Asparagus. Asparagus-LD50 for mice was 67 000±292 mg/kg BW. One ninth of the dose was given once a day per os for thirty days. The results reflect that asparagus-Qianyuan 9 inhibited growth development of mice.
- 【文献出处】 贵阳医学院学报 ,JOURNAL OF GUIYANG MEDICAL COLLEGE , 编辑部邮箱 ,1995年01期
- 【分类号】R979.1
- 【被引频次】13
- 【下载频次】79