【摘要】 原卟啉（ＰＰ）、血卟啉（ＨＰ）和双卟啉醚、酯混合物（ＤＨＥ）对蛋白质主链结构的光敏损伤特征─—兼论它们在Ｈａｌａ细胞死亡中的作用许以明，张志义，杨勇正（中国科学院生物物理研究所北京１００１０１）ＣｈａｒａｃｔｃｆｏｆＰｈｏｔｏｓｅｎｓｉｔｉｖｅＤａｍ...更多还原

【Abstract】 Abstract Laser Raman spectroscopy was used to investigate the microcosmic and photosensitive damage of active componets PP， HP and DHE of porphyrin’s drug to the structure of the main-chain of protein （lysozyme ）.The results indecated that the damages of the three active componete to the structure of lysozyme are considerably different ： The damages of PP toβ-sheet andβ-turn of the structure of the main-chain were stronger than the damages of HP and DHE to that and the resuIt was found in a dose－independent way，It is suggested that the damages to protein mainly dependent on the structure of PP，HP and DHE.更多还原